The day-night pattern of colonic contractility is not impaired in type 1 diabetes and distal symmetric polyneuropathy

Colonic contractility normally shows circadian variability regulated by sleep and especially food intake. However, individuals with type 1 diabetes have a reduced or even absent gastrocolic response to meal, indicating that colonic may be affected the disease. We hypothesized distal symmetric polyneuropathy (DSPN) decreased motility (expressed as index) of colon increase in index from night morning compared healthy controls without DSPN. Cohorts 35 DSPN, 40 28 were included this post-hoc, cross-sectional analysis. investigated, using wireless capsule measures pH, temperature, pressure throughout gastrointestinal tract, whether controls, exhibit altered evening, night, morning. Max amplitude, mean peak contraction, calculated at afore-designated times. Motility tended higher DSPN evening (P = .064), but effect size was small (1.74%). There no difference between groups evening. Furthermore, there max contraction morning, night. As expected, overall increased all groups, generally peaked almost Type and/or did not impair any time point. Contractility unaffected